Endocrine hormone secretion

Across TCGA patient cohorts, RNA activity of the Endocrine hormone secretion pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPP1, ADM, and GJA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocrine hormone secretion activity versus SPP1 in GBM (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SPP1 →	+1.408	+0.257	<.001	<.001	3	6
PDAC	ADM →	+1.371	+0.339	<.001	<.001	3	6
LSCC	GJA1 →	+1.218	+0.690	<.001	<.001	3	6
OV	CERCAM →	+0.774	+0.578	<.001	.001	3	6
OV	COPZ2 →	+0.922	+0.645	.001	<.001	3	6
LSCC	LOX →	+0.908	+0.603	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060986 vs SPP1 — GBM

Explore this scatter interactively →