Endocrine hormone secretion

Across TCGA cell cohorts, RNA activity of the Endocrine hormone secretion pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCTP, CEP41, and ABCD4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PCTP grouped by Endocrine hormone secretion-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PCTP →	-2.295	-1.346	.003	.002	2	6
OVARY	CEP41 →	+1.268	+1.227	.001	.002	3	5
BLOOD_Myeloma	ABCD4 →	+1.164	+1.735	.008	.002	3	4
BONE	METAP2 →	+0.805	+1.829	<.001	<.001	3	4
OVARY	TMED4 →	-0.589	-1.409	<.001	<.001	3	4
OVARY	ARL2 →	+0.759	+1.113	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PCTP by Endocrine hormone secretion activity — LUNG_SCLC

Explore this box plot interactively →