Endocrine hormone secretion

Across TCGA cell cohorts, RNA activity of the Endocrine hormone secretion pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNQ2, PRPF3, and NSUN4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCNQ2 grouped by Endocrine hormone secretion-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	KCNQ2 →	-0.188	-0.245	<.001	<.001	3	5
OESOPHAGUS	PRPF3 →	-0.466	-0.187	<.001	.004	3	4
LIVER	NSUN4 →	+0.355	+0.394	.004	.002	2	5
BLOOD_Myeloma	CCDC126 →	-0.255	-1.619	.008	<.001	3	4
BONE	SERINC3 →	-0.260	-0.291	<.001	.001	3	4
BONE	AJAP1 →	-0.167	-0.271	.003	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCNQ2 by Endocrine hormone secretion activity — PANCREAS

Explore this box plot interactively →