Coronary artery morphogenesis

Across TCGA patient cohorts, RNA activity of the Coronary artery morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOMM22, NRP1, and SYNPO_S833, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Coronary artery morphogenesis activity versus TOMM22 in LSCC (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TOMM22 →	-0.163	-0.063	.009	.001	3	4
LSCC	NRP1 →	+0.243	+0.063	<.001	<.001	3	4
PDAC	SYNPO_S833 →	+0.512	+0.041	<.001	<.001	3	4
PDAC	C7 →	+0.561	+0.060	<.001	<.001	3	4
CCRCC	MPRIP →	+0.230	+0.072	.003	<.001	3	4
PDAC	PRELP →	+0.925	+0.056	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060982 vs TOMM22 — LSCC

Explore this scatter interactively →