Coronary artery morphogenesis

Across TCGA patient cohorts, RNA activity of the Coronary artery morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRP2, AP3B1, and TBL1XR1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Coronary artery morphogenesis activity versus LRP2 in BRCA (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LRP2 →	+1.922	+0.508	<.001	<.001	3	4
LSCC	AP3B1 →	-0.234	-0.337	<.001	.006	3	3
LSCC	TBL1XR1 →	-0.648	-0.511	.004	.006	3	3
LSCC	RPL7P52 →	-0.394	-0.584	.001	.001	3	3
LSCC	DCUN1D1 →	-0.466	-0.342	.006	.006	3	3
CCRCC	NDUFS8 →	+0.335	+0.257	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060982 vs LRP2 — BRCA

Explore this scatter interactively →