Coronary artery morphogenesis

Across TCGA cell cohorts, RNA activity of the Coronary artery morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNRPA1, LINS1, and CTNNAL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SNRPA1 grouped by Coronary artery morphogenesis-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SNRPA1 →	+0.655	+0.878	.005	.008	3	5
OVARY	LINS1 →	+0.870	+1.169	<.001	.001	3	5
BLOOD_Lymphoma	CTNNAL1 →	+1.147	+1.587	.003	<.001	3	4
LARGE_INTESTINE	CEACAM19 →	+0.661	+0.986	.008	.001	3	4
BONE	DDX17 →	+0.754	+1.478	.005	.001	3	4
BONE	AEBP2 →	+0.564	+1.213	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNRPA1 by Coronary artery morphogenesis activity — OVARY

Explore this box plot interactively →