Coronary artery morphogenesis

Across TCGA cell cohorts, RNA activity of the Coronary artery morphogenesis pathway is significantly associated with the drug response of multiple features, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Uprosertib, ULK1_4989, and Capivasertib, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Uprosertib grouped by Coronary artery morphogenesis-low versus -high activity in CNS.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Uprosertib →	+0.502	+0.332	.034	.036	2	1
CNS	ULK1_4989 →	+1.093	+0.498	.012	.043	2	1
SKIN	Capivasertib →	+0.520	+1.987	.045	.007	2	1
SKIN	Bleomycin (10 uM) →	+0.700	+1.752	.013	.002	2	1
SKIN	JAK3_7406 →	+0.290	+1.752	.028	.002	2	1
SKIN	GSK2801 →	+0.266	+1.987	.041	.007	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Uprosertib by Coronary artery morphogenesis activity — CNS

Explore this box plot interactively →