Vasculogenesis involved in coronary vascular morphogenesis

Across TCGA patient cohorts, RNA activity of the Vasculogenesis involved in coronary vascular morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGFBR3, EFCAB14, and TGFBR2, each associated with the pathway in up to 30 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vasculogenesis involved in coronary vascular morphogenesis activity versus TGFBR3 in THYM (Pearson r = 0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	TGFBR3 →	+2.181	+0.174	<.001	<.001	3	30
KICH	EFCAB14 →	+0.949	+0.075	<.001	<.001	2	30
THYM	TGFBR2 →	+1.690	+0.144	<.001	<.001	3	29
THYM	PLPP3 →	+1.924	+0.154	<.001	<.001	3	28
KIRC	DLC1 →	+1.077	+0.089	<.001	<.001	3	28
THYM	SPRED1 →	+1.771	+0.169	<.001	<.001	3	28

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060979 vs TGFBR3 — THYM

Explore this scatter interactively →