Vasculogenesis involved in coronary vascular morphogenesis

Across TCGA patient cohorts, RNA activity of the Vasculogenesis involved in coronary vascular morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TGFBR3, BANF1, and LAMA5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vasculogenesis involved in coronary vascular morphogenesis activity versus TGFBR3 in LUAD (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TGFBR3 →	+0.703	+0.119	<.001	<.001	3	7
CCRCC	BANF1 →	+0.306	+0.094	<.001	<.001	3	6
OV	LAMA5 →	+0.332	+0.076	.001	.003	3	6
LUAD	HMGN4 →	+0.568	+0.095	<.001	<.001	3	6
CCRCC	RBP7 →	+0.805	+0.083	<.001	<.001	3	6
CCRCC	GBF1 →	-0.149	-0.091	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060979 vs TGFBR3 — LUAD

Explore this scatter interactively →