Vasculogenesis involved in coronary vascular morphogenesis

Across TCGA cell cohorts, RNA activity of the Vasculogenesis involved in coronary vascular morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM19, FAM204A, and PCNP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM19 grouped by Vasculogenesis involved in coronary vascular morphogenesis-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TMEM19 →	+0.520	+1.029	.003	.001	3	4
BONE	FAM204A →	+0.796	+1.640	.001	.001	3	4
LUNG_NSCLC_LUSC	PCNP →	+0.834	+1.180	.002	.006	3	4
BLOOD_Lymphoma	CORO1B →	+2.931	+1.381	.001	.003	2	5
CNS	TAF1B →	+0.499	+1.097	.003	<.001	3	4
STOMACH	ADAMTS13 →	+0.881	+1.258	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM19 by Vasculogenesis involved in coronary vascular morphogenesis activity — SKIN

Explore this box plot interactively →