Vasculogenesis involved in coronary vascular morphogenesis

Across TCGA cell cohorts, RNA activity of the Vasculogenesis involved in coronary vascular morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NGF, LGALS14, and PHLDA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NGF grouped by Vasculogenesis involved in coronary vascular morphogenesis-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NGF →	-0.172	-0.119	.009	.008	3	4
BONE	LGALS14 →	-0.334	-1.335	.002	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	PHLDA1 →	+0.229	+1.296	.003	.003	3	3
LUNG_NSCLC_LUAD	FABP4 →	-0.078	-0.575	.005	.003	3	3
LUNG_NSCLC_LUAD	UGT1A3 →	+0.177	+0.790	<.001	.005	3	3
OVARY	COL11A1 →	-0.173	-0.661	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NGF by Vasculogenesis involved in coronary vascular morphogenesis activity — SKIN

Explore this box plot interactively →