Angiogenesis involved in coronary vascular morphogenesis

Across TCGA cell cohorts, RNA activity of the Angiogenesis involved in coronary vascular morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPAT, CCDC168, and DPF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPAT grouped by Angiogenesis involved in coronary vascular morphogenesis-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PPAT →	+0.848	+1.455	.002	<.001	3	5
OVARY	CCDC168 →	+0.016	+0.925	.008	.004	2	6
URINARY_TRACT	DPF1 →	+1.701	+1.489	<.001	.001	2	6
BLOOD_Leukemia	TAF15 →	+0.783	+1.484	<.001	<.001	3	5
OESOPHAGUS	LIN52 →	+0.718	+1.501	.003	<.001	3	4
PANCREAS	DNAJC7 →	+0.491	+1.100	.006	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPAT by Angiogenesis involved in coronary vascular morphogenesis activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →