Angiogenesis involved in coronary vascular morphogenesis

Across TCGA cell cohorts, RNA activity of the Angiogenesis involved in coronary vascular morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATOH8, FAM199X, and KCNS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATOH8 grouped by Angiogenesis involved in coronary vascular morphogenesis-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ATOH8 →	-0.176	-0.128	.006	.007	3	4
LUNG_NSCLC_LUSC	FAM199X →	-0.234	-0.283	.002	.003	3	3
BONE	KCNS1 →	-0.393	-1.479	.001	.002	3	3
LUNG_NSCLC_LUSC	HCLS1 →	-0.158	-0.185	<.001	.002	3	3
LUNG_NSCLC_LUSC	ZNF833P →	+0.295	+0.169	.008	.001	2	4
BLOOD_Leukemia	ANKRD30A →	-0.200	-0.709	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATOH8 by Angiogenesis involved in coronary vascular morphogenesis activity — KIDNEY

Explore this box plot interactively →