Angiogenesis involved in coronary vascular morphogenesis

Across TCGA cell cohorts, RNA activity of the Angiogenesis involved in coronary vascular morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NRP1, TGFBR1, and FRMD6, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Angiogenesis involved in coronary vascular morphogenesis activity versus NRP1 in BREAST (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NRP1 →	+3.153	+0.905	<.001	<.001	3	17
BLOOD_Leukemia	TGFBR1 →	+1.535	+1.115	<.001	<.001	3	11
BONE	FRMD6 →	+3.689	+1.119	<.001	<.001	3	11
BONE	SGPP1 →	+1.048	+1.011	<.001	.001	3	9
BONE	AXL →	+5.649	+0.898	<.001	<.001	3	9
LIVER	SNAPC1 →	+2.111	+0.165	<.001	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060978 vs NRP1 — BREAST

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