Coronary vasculature morphogenesis

Across TCGA patient cohorts, RNA activity of the Coronary vasculature morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KANK2_S540, ANG, and RSU1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Coronary vasculature morphogenesis activity versus KANK2_S540 in CCRCC (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	KANK2_S540 →	+0.559	+0.074	<.001	<.001	3	8
BRCA	ANG →	+0.478	+0.035	.002	.001	3	8
UCEC	RSU1 →	+0.597	+0.117	<.001	<.001	3	7
UCEC	SORBS3 →	+0.553	+0.098	.001	<.001	3	7
BRCA	TLN2 →	+0.422	+0.038	<.001	<.001	3	7
GBM	VIM →	+0.408	+0.065	.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060977 vs KANK2_S540 — CCRCC

Explore this scatter interactively →