Coronary vasculature morphogenesis

Across TCGA patient cohorts, RNA activity of the Coronary vasculature morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAM21, MAST4, and DMAC2L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Coronary vasculature morphogenesis activity versus ADAM21 in GBM (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ADAM21 →	+0.436	+0.480	.001	.006	3	3
CCRCC	MAST4 →	+0.774	+0.456	<.001	.003	3	3
BRCA	DMAC2L →	+0.460	+0.579	<.001	<.001	3	3
BRCA	SPATA18 →	+0.928	+0.497	.001	.002	3	3
BRCA	MTMR10 →	+0.411	+0.517	.007	.002	3	3
BRCA	OPRPN →	+0.985	+0.468	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060977 vs ADAM21 — GBM

Explore this scatter interactively →