Coronary vasculature morphogenesis

Across TCGA cell cohorts, RNA activity of the Coronary vasculature morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS6KB1, PAFAH1B2, and LINS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPS6KB1 grouped by Coronary vasculature morphogenesis-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RPS6KB1 →	+0.658	+0.815	.002	.007	3	5
SOFT_TISSUE	PAFAH1B2 →	+0.679	+1.221	.004	.002	3	5
OVARY	LINS1 →	+0.701	+1.261	<.001	<.001	3	4
PANCREAS	DDX42 →	+0.551	+0.899	.001	.001	3	4
BREAST	GDF9 →	+0.249	+0.576	.004	.005	2	5
BONE	FNBP4 →	+1.458	+1.396	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPS6KB1 by Coronary vasculature morphogenesis activity — LUNG_SCLC

Explore this box plot interactively →