Coronary vasculature morphogenesis

Across TCGA cell cohorts, RNA activity of the Coronary vasculature morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEC24D, PLIN3, and SLC25A19, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Coronary vasculature morphogenesis activity versus SEC24D in BONE (Pearson r = 0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SEC24D →	+2.160	+1.583	.004	<.001	3	4
BREAST	PLIN3 →	+1.299	+2.328	.002	<.001	3	4
CNS	SLC25A19 →	-0.788	-0.930	.001	.001	3	4
BREAST	NAV1 →	+2.994	+2.328	<.001	<.001	3	4
BREAST	TIMP2 →	+5.629	+2.455	.005	<.001	3	4
BREAST	PLEKHH1 →	-2.516	-2.328	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060977 vs SEC24D — BONE

Explore this scatter interactively →