Coronary vasculature development

Across TCGA cell cohorts, RNA activity of the Coronary vasculature development pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NRP1, GXYLT2, and CD59, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Coronary vasculature development activity versus NRP1 in OVARY (Pearson r = 0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	NRP1 →	+3.066	+1.464	.003	.001	3	4
BREAST	GXYLT2 →	+2.664	+2.459	<.001	<.001	3	4
BREAST	CD59 →	+2.230	+1.993	.001	.005	3	4
OVARY	AIF1L →	-4.582	-1.464	<.001	.001	3	4
OVARY	GLIPR1 →	+2.846	+1.464	.005	.001	3	4
OVARY	CADPS2 →	+1.495	+1.464	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060976 vs NRP1 — OVARY

Explore this scatter interactively →