Cell migration involved in heart development

Across TCGA patient cohorts, RNA activity of the Cell migration involved in heart development pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MT-CYB, SPARC, and DDR2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell migration involved in heart development activity versus MT-CYB in LUAD (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MT-CYB →	-0.492	-0.321	.003	.003	3	4
LSCC	SPARC →	+0.670	+0.566	.001	.004	3	4
BRCA	DDR2 →	+0.676	+0.392	<.001	.001	3	4
BRCA	VSTM4 →	+0.830	+0.639	<.001	<.001	3	4
UCEC	JAM3 →	+0.514	+0.560	.006	.003	3	4
LSCC	CLMP →	+0.623	+0.703	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060973 vs MT-CYB — LUAD

Explore this scatter interactively →