Cell migration involved in heart development

Across TCGA cell cohorts, RNA activity of the Cell migration involved in heart development pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC42, TFAP2C, and SNAI2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDC42 grouped by Cell migration involved in heart development-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CDC42 →	-0.459	-1.319	<.001	<.001	3	6
BLOOD_Myeloma	TFAP2C →	-0.257	-2.400	.006	<.001	3	5
BLOOD_Myeloma	SNAI2 →	-0.264	-1.986	.008	.005	3	4
BLOOD_Myeloma	DLX5 →	-0.366	-2.024	<.001	.002	3	4
BLOOD_Leukemia	EDN1 →	-0.320	-1.090	.001	<.001	3	4
STOMACH	PLEKHH2 →	+0.253	+0.280	.009	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDC42 by Cell migration involved in heart development activity — LARGE_INTESTINE

Explore this box plot interactively →