Cell migration involved in heart development

Across TCGA cell cohorts, RNA activity of the Cell migration involved in heart development pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FKBP7, OTUD3, and CAPN15, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FKBP7 grouped by Cell migration involved in heart development-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FKBP7 →	+1.229	+0.223	.008	.002	3	4
LUNG_NSCLC_LUAD	OTUD3 →	+0.510	+0.573	.001	.001	3	3
OVARY	CAPN15 →	-0.619	-0.844	.001	.005	3	3
OVARY	PRKD2 →	-0.635	-0.907	.002	.002	2	4
OVARY	RHBDF1 →	-1.170	-1.369	<.001	<.001	3	3
BREAST	SLC9A3 →	-1.003	-0.819	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FKBP7 by Cell migration involved in heart development activity — STOMACH

Explore this box plot interactively →