Cell migration involved in heart development

Across TCGA cell cohorts, RNA activity of the Cell migration involved in heart development pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDE6A, GP1BB, and RPS5, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PDE6A grouped by Cell migration involved in heart development-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PDE6A →	+0.346	+0.275	.002	.001	3	2
CNS	GP1BB →	+0.225	+0.339	.002	.001	2	3
CNS	RPS5 →	+0.227	+0.302	.004	.004	3	1
CNS	RAB10 →	+0.397	+0.368	.004	<.001	3	1
OVARY	ARHGEF7 →	-0.097	-0.298	<.001	.004	3	1
OVARY	OCA2 →	+0.295	+0.281	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PDE6A by Cell migration involved in heart development activity — OVARY

Explore this box plot interactively →