Cell migration involved in heart development

Across TCGA cell cohorts, RNA activity of the Cell migration involved in heart development pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF200, CCDC117, and PSMC3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell migration involved in heart development activity versus ZNF200 in CNS (Pearson r = -0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ZNF200 →	-0.358	-0.284	.001	<.001	3	3
OVARY	CCDC117 →	-1.442	-0.264	<.001	.006	3	3
OVARY	PSMC3 →	-0.590	-0.241	.004	.004	3	3
CNS	ZNF85 →	-0.626	-0.209	.004	.002	3	2
CNS	HSD17B7 →	-1.064	-0.220	.006	.008	3	2
CNS	TIPRL →	-0.769	-0.267	.005	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060973 vs ZNF200 — CNS

Explore this scatter interactively →