Embryonic heart tube left/right pattern formation

Across TCGA patient cohorts, RNA activity of the Embryonic heart tube left/right pattern formation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCN1B, APBB2, and INSR, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic heart tube left/right pattern formation activity versus SCN1B in BRCA (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SCN1B →	+0.674	+0.228	<.001	.004	3	3
HNSC	APBB2 →	+0.672	+0.161	.003	.008	3	3
HNSC	INSR →	+0.646	+0.148	.001	.001	3	3
HNSC	TTN-AS1 →	+0.546	+0.191	.001	.001	3	3
BRCA	EFHD1 →	+0.948	+0.327	.005	.007	3	3
BRCA	SERTAD3 →	+0.361	+0.260	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060971 vs SCN1B — BRCA

Explore this scatter interactively →