Regulation of gene silencing by regulatory ncRNA

Across TCGA cell cohorts, RNA activity of the Regulation of gene silencing by regulatory ncRNA pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ST3GAL1, APOL2, and IFI44L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ST3GAL1 grouped by Regulation of gene silencing by regulatory ncRNA-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ST3GAL1 →	+2.293	+0.295	.002	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	APOL2 →	-2.126	-0.127	.006	.009	3	4
SKIN	IFI44L →	+2.256	+0.230	<.001	.002	3	4
LUNG_NSCLC_LUAD	CTSS →	+2.083	+0.159	.002	.002	3	4
LUNG_NSCLC_LUAD	CRYBG1 →	+1.789	+0.179	.004	.001	3	4
LUNG_NSCLC_LUAD	PAOX →	-0.924	-0.227	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ST3GAL1 by Regulation of gene silencing by regulatory ncRNA activity — URINARY_TRACT

Explore this box plot interactively →