Regulation of gene silencing by regulatory ncRNA

Across TCGA cell cohorts, RNA activity of the Regulation of gene silencing by regulatory ncRNA pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBE2I, KIF4B, and PRPF38A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of gene silencing by regulatory ncRNA activity versus UBE2I in LUNG_SCLC (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	UBE2I →	+0.540	+0.197	.001	.003	3	6
PANCREAS	KIF4B →	+0.084	+0.213	.001	.003	3	6
BLOOD_Leukemia	PRPF38A →	+0.480	+0.182	.003	.004	3	6
BLOOD_Leukemia	RBBP4 →	+1.059	+0.206	<.001	<.001	3	6
LUNG_SCLC	EZH2 →	+0.598	+0.222	.005	.002	3	6
LIVER	CDCA8 →	+0.841	+0.197	.003	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060966 vs UBE2I — LUNG_SCLC

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