Endocardial cell differentiation

Across TCGA patient cohorts, RNA activity of the Endocardial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SARC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOX18, ADCY4, and DIPK2B, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocardial cell differentiation activity versus SOX18 in SARC (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	SOX18 →	+1.420	+0.103	<.001	<.001	3	31
SARC	ADCY4 →	+1.142	+0.097	<.001	<.001	3	30
PCPG	DIPK2B →	+1.393	+0.064	<.001	<.001	3	30
SCLC	ROBO4 →	+1.451	+0.239	<.001	<.001	3	30
PCPG	ARHGEF15 →	+1.202	+0.065	<.001	<.001	3	30
PCPG	FLT4 →	+1.269	+0.064	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060956 vs SOX18 — SARC

Explore this scatter interactively →