Endocardial cell differentiation

Across TCGA patient cohorts, RNA activity of the Endocardial cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZNF462_S2172, CST6, and RRBP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocardial cell differentiation activity versus ZNF462_S2172 in CCRCC (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ZNF462_S2172 →	+0.461	+0.092	<.001	<.001	3	5
OV	CST6 →	-1.166	-0.065	.002	.009	3	4
CCRCC	RRBP1 →	-0.297	-0.074	<.001	<.001	3	4
CCRCC	SHANK3_T1227 →	+0.385	+0.070	<.001	<.001	3	4
LSCC	VPS11 →	-0.130	-0.065	<.001	<.001	3	4
CCRCC	FMNL1_S624 →	-0.280	-0.069	.009	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060956 vs ZNF462_S2172 — CCRCC

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