Endocardial cell differentiation

Across TCGA patient cohorts, RNA activity of the Endocardial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GALNT6, CSNK2A1, and FBXO10, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocardial cell differentiation activity versus GALNT6 in BRCA (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GALNT6 →	-0.956	-0.466	.001	<.001	3	3
UCEC	CSNK2A1 →	-0.246	-0.340	.001	.006	3	3
UCEC	FBXO10 →	-0.212	-0.404	.006	.001	3	3
UCEC	SLX4IP →	-0.440	-0.510	.001	.001	3	3
UCEC	PUS10 →	-0.267	-0.421	.004	<.001	3	3
PDAC	SMAD3 →	-0.411	-0.496	.009	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060956 vs GALNT6 — BRCA

Explore this scatter interactively →