Cardiac vascular smooth muscle cell differentiation

Across TCGA patient cohorts, RNA activity of the Cardiac vascular smooth muscle cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FLT1, NMT1, and RIT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac vascular smooth muscle cell differentiation activity versus FLT1 in CCRCC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	FLT1 →	+0.774	+0.086	<.001	.002	3	5
OV	NMT1 →	-0.245	-0.069	.001	.002	3	4
PDAC	RIT1 →	+0.429	+0.067	<.001	<.001	3	4
CCRCC	SPCS2 →	-0.518	-0.071	.001	.003	3	4
UCEC	PKP3_S180 →	-0.770	-0.068	<.001	.001	3	4
PDAC	BRD3_S263 →	+0.237	+0.066	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060947 vs FLT1 — CCRCC

Explore this scatter interactively →