Cardiac muscle cell fate commitment

Across TCGA patient cohorts, RNA activity of the Cardiac muscle cell fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the UCS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBX3, TBX18, and PRRX2, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac muscle cell fate commitment activity versus TBX3 in UCS (Pearson r = -0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	TBX3 →	+1.940	+0.107	.001	.001	3	20
ACC	TBX18 →	-0.831	-0.086	<.001	<.001	3	17
ACC	PRRX2 →	-1.872	-0.068	<.001	.001	3	15
THYM	DPT →	-2.226	-0.088	<.001	<.001	3	15
THYM	HTRA3 →	-1.603	-0.096	<.001	<.001	2	16
ACC	SYDE1 →	-0.810	-0.072	.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060923 vs TBX3 — UCS

Explore this scatter interactively →