Cardiac muscle cell fate commitment

Across TCGA patient cohorts, RNA activity of the Cardiac muscle cell fate commitment pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRGAP1_S906, PCBP1, and GALK2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac muscle cell fate commitment activity versus SRGAP1_S906 in OV (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SRGAP1_S906 →	+0.567	+0.116	<.001	<.001	3	5
OV	PCBP1 →	+0.198	+0.080	.003	.002	3	5
LUAD	GALK2 →	+0.347	+0.098	<.001	<.001	3	5
CCRCC	CTHRC1 →	-0.753	-0.089	.001	.005	3	5
CCRCC	PKP2_S251 →	+0.653	+0.117	.002	.001	3	5
UCEC	TBX3_S456 →	+0.512	+0.123	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060923 vs SRGAP1_S906 — OV

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