Cardiac muscle cell fate commitment

Across TCGA cell cohorts, RNA activity of the Cardiac muscle cell fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRHL2, MUC20, and TMEM87A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GRHL2 grouped by Cardiac muscle cell fate commitment-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	GRHL2 →	-1.878	-0.837	.002	.005	3	5
UPPER_AERODIGESTIVE_TRACT	MUC20 →	-3.613	-1.454	<.001	<.001	3	5
OVARY	TMEM87A →	-0.655	-1.078	.003	.001	3	4
OVARY	C6orf132 →	-2.490	-1.055	<.001	.001	3	4
BLOOD_Lymphoma	MAP10 →	-1.170	-1.293	<.001	.008	2	5
OVARY	TGM1 →	-1.619	-1.038	.003	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GRHL2 by Cardiac muscle cell fate commitment activity — OVARY

Explore this box plot interactively →