Positive regulation of macrophage cytokine production

Across TCGA patient cohorts, RNA activity of the Positive regulation of macrophage cytokine production pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, SAMSN1_S23, and SASH3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of macrophage cytokine production activity versus RCSD1 in GBM (Pearson r = 0.74).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RCSD1 →	+0.685	+0.132	<.001	<.001	3	10
BRCA	SAMSN1_S23 →	+0.832	+0.054	<.001	<.001	3	10
GBM	SASH3 →	+0.603	+0.143	<.001	<.001	3	10
LSCC	SEPTIN1 →	+0.690	+0.087	<.001	<.001	3	10
GBM	SKAP2 →	+0.871	+0.133	<.001	<.001	3	10
LSCC	STK4 →	+0.307	+0.072	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060907 vs RCSD1 — GBM

Explore this scatter interactively →