Positive regulation of macrophage cytokine production

Across TCGA cell cohorts, RNA activity of the Positive regulation of macrophage cytokine production pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB31, CCDC9B, and GET4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB31 grouped by Positive regulation of macrophage cytokine production-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	RAB31 →	-2.565	-1.856	<.001	<.001	3	4
OVARY	CCDC9B →	-2.104	-0.902	<.001	.002	3	4
STOMACH	GET4 →	-0.812	-1.202	.004	.003	3	4
LIVER	BTBD6 →	-2.224	-1.284	.004	<.001	3	4
LUNG_NSCLC_LUAD	RETSAT →	-0.686	-0.791	.005	.002	3	4
UPPER_AERODIGESTIVE_TRACT	C15orf40 →	-0.930	-1.308	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB31 by Positive regulation of macrophage cytokine production activity — URINARY_TRACT

Explore this box plot interactively →