Positive regulation of macrophage cytokine production

Across TCGA cell cohorts, RNA activity of the Positive regulation of macrophage cytokine production pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA3, LAMB3, and HLA-F, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of macrophage cytokine production activity versus ANXA3 in BREAST (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ANXA3 →	+2.586	+0.427	.004	<.001	3	6
LUNG_NSCLC_LUSC	LAMB3 →	+7.103	+0.601	<.001	.006	3	6
BLOOD_Leukemia	HLA-F →	+2.869	+0.264	<.001	.001	2	7
BLOOD_Lymphoma	LBX2 →	+1.583	+0.341	<.001	.001	3	5
URINARY_TRACT	PSMB8 →	+2.449	+0.489	.002	<.001	3	5
BLOOD_Lymphoma	SFXN2 →	-1.424	-0.300	.002	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060907 vs ANXA3 — BREAST

Explore this scatter interactively →