Semicircular canal development

Across TCGA patient cohorts, RNA activity of the Semicircular canal development pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DPYSL3, PARP4, and EMILIN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Semicircular canal development activity versus DPYSL3 in UCEC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DPYSL3 →	+0.675	+0.094	.002	.004	3	6
PDAC	PARP4 →	-0.239	-0.053	.004	<.001	3	6
OV	EMILIN1 →	+0.761	+0.055	<.001	.007	3	5
UCEC	HMCN1 →	+0.673	+0.116	<.001	.003	3	5
BRCA	KANK2 →	+0.547	+0.093	<.001	<.001	3	5
OV	MMP2 →	+0.724	+0.073	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060872 vs DPYSL3 — UCEC

Explore this scatter interactively →