Semicircular canal development

Across TCGA cell cohorts, RNA activity of the Semicircular canal development pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PGLYRP1, RARS1, and RAD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PGLYRP1 grouped by Semicircular canal development-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PGLYRP1 →	-0.132	-0.889	.006	.003	3	4
LUNG_NSCLC_LUSC	RARS1 →	+0.793	+1.386	.008	.006	3	4
STOMACH	RAD1 →	-0.931	-1.409	.004	.002	3	4
STOMACH	FBXO33 →	+0.462	+1.417	.008	.007	3	4
OVARY	VAV3 →	-2.250	-1.096	.001	<.001	3	4
SOFT_TISSUE	MT-ND5 →	-1.390	-1.533	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PGLYRP1 by Semicircular canal development activity — BREAST

Explore this box plot interactively →