Establishment of blood-brain barrier

Across TCGA patient cohorts, RNA activity of the Establishment of blood-brain barrier pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSMD2, COL6A1, and SCT, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of blood-brain barrier activity versus CSMD2 in LSCC (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CSMD2 →	-0.640	-0.401	.001	.009	3	4
LSCC	COL6A1 →	-0.838	-0.429	.008	.006	1	6
BRCA	SCT →	-0.759	-0.168	<.001	.001	3	4
LUAD	ISLR →	-0.760	-0.462	.001	.005	3	4
LUAD	CNIH3 →	-0.511	-0.418	.001	.002	3	4
GBM	COL11A1 →	-1.446	-0.138	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060856 vs CSMD2 — LSCC

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