Establishment of blood-brain barrier

Across TCGA cell cohorts, RNA activity of the Establishment of blood-brain barrier pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CA2, ARVCF, and MARK3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CA2 grouped by Establishment of blood-brain barrier-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CA2 →	+2.907	+1.159	.001	<.001	3	4
PANCREAS	ARVCF →	+1.386	+1.179	.007	.004	3	4
LUNG_NSCLC_LUSC	MARK3 →	-0.578	-0.774	.002	.009	3	4
STOMACH	SNAI2 →	-3.660	-1.454	<.001	<.001	3	4
BONE	GTPBP1 →	+0.906	+1.453	.005	<.001	3	3
BONE	TMEM9 →	+0.829	+1.480	.003	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CA2 by Establishment of blood-brain barrier activity — STOMACH

Explore this box plot interactively →