Establishment of blood-brain barrier

Across TCGA cell cohorts, RNA activity of the Establishment of blood-brain barrier pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPIE, CR1, and PPP1R16B, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPIE grouped by Establishment of blood-brain barrier-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PPIE →	+0.480	+1.562	.001	<.001	3	2
LUNG_NSCLC_LUAD	CR1 →	+0.197	+1.356	<.001	<.001	3	2
LUNG_NSCLC_LUAD	PPP1R16B →	+0.133	+1.582	.003	<.001	3	1
LUNG_NSCLC_LUAD	STX4 →	+0.126	+1.529	.005	<.001	3	1
LUNG_NSCLC_LUAD	UBE3A →	-0.183	-1.543	.002	<.001	3	1
LUNG_NSCLC_LUAD	PRPF3 →	+0.730	+1.672	.006	<.001	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPIE by Establishment of blood-brain barrier activity — PANCREAS

Explore this box plot interactively →