Establishment of blood-brain barrier

Across TCGA cell cohorts, RNA activity of the Establishment of blood-brain barrier pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRDM12, EHF, and KLRG1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of blood-brain barrier activity versus PRDM12 in LUNG_NSCLC_LUAD (Pearson r = -0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PRDM12 →	-0.170	-1.354	.006	<.001	3	2
LUNG_NSCLC_LUAD	EHF →	+4.217	+1.595	.002	<.001	3	2
LUNG_NSCLC_LUAD	KLRG1 →	-0.839	-1.340	<.001	<.001	3	2
LUNG_NSCLC_LUAD	FAHD2B →	-1.095	-1.254	.005	<.001	3	2
LUNG_NSCLC_LUAD	NLRX1 →	-1.600	-1.625	.002	<.001	3	2
LUNG_NSCLC_LUAD	NAXE →	-0.643	-1.510	.008	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060856 vs PRDM12 — LUNG_NSCLC_LUAD

Explore this scatter interactively →