Arterial endothelial cell differentiation

Across TCGA patient cohorts, RNA activity of the Arterial endothelial cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TMEM100_S121, NEXN_S569, and RFX7_S1128, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Arterial endothelial cell differentiation activity versus TMEM100_S121 in CCRCC (Pearson r = -0.05).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TMEM100_S121 →	+1.937	+0.982	<.001	<.001	3	6
UCEC	NEXN_S569 →	+1.148	+0.832	<.001	<.001	3	4
OV	RFX7_S1128 →	+1.904	+1.327	.004	.001	3	3
PDAC	CHMP4B →	-0.222	-0.733	<.001	<.001	3	3
UCEC	HSPG2_S888 →	+1.447	+0.746	<.001	<.001	3	3
UCEC	MFAP4 →	+1.279	+0.707	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060842 vs TMEM100_S121 — CCRCC

Explore this scatter interactively →