Venous blood vessel development

Across TCGA patient cohorts, RNA activity of the Venous blood vessel development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERPINA7, SLC25A5, and COL15A1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Venous blood vessel development activity versus SERPINA7 in OV (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SERPINA7 →	+0.646	+0.071	<.001	<.001	3	6
OV	SLC25A5 →	-0.477	-0.051	.003	.008	3	6
OV	COL15A1 →	+0.525	+0.052	.002	.003	2	7
GBM	COL1A1 →	+0.689	+0.051	.009	.004	3	6
GBM	COL1A2 →	+0.690	+0.071	.003	<.001	3	6
OV	COL4A2 →	+0.671	+0.092	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060841 vs SERPINA7 — OV

Explore this scatter interactively →