Venous blood vessel development

Across TCGA cell cohorts, RNA activity of the Venous blood vessel development pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INO80C, SPRY3, and PIK3R2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, INO80C grouped by Venous blood vessel development-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	INO80C →	+1.331	+1.281	.001	.002	3	4
LIVER	SPRY3 →	-0.192	-1.177	.002	.001	3	4
CNS	PIK3R2 →	+1.021	+0.823	.006	.002	3	3
CNS	SORBS3 →	+0.876	+0.637	.009	<.001	3	3
CNS	CMIP →	+0.982	+0.615	.009	.009	3	3
CNS	ADAM9 →	+0.982	+0.701	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

INO80C by Venous blood vessel development activity — STOMACH

Explore this box plot interactively →