Artery development

Across TCGA patient cohorts, RNA activity of the Artery development pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPARC, CNRIP1, and RECK, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Artery development activity versus SPARC in OV (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SPARC →	+1.852	+1.151	<.001	<.001	3	7
OV	CNRIP1 →	+1.009	+0.997	<.001	<.001	3	7
BRCA	RECK →	+0.605	+0.568	<.001	<.001	3	7
CCRCC	AOC3 →	+1.057	+0.778	<.001	<.001	3	7
OV	COL8A1 →	+1.874	+0.866	<.001	<.001	3	7
CCRCC	TAGLN →	+1.479	+0.779	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060840 vs SPARC — OV

Explore this scatter interactively →