Artery development

Across TCGA cell cohorts, RNA activity of the Artery development pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR3G, PSMA4, and NDUFAB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POLR3G grouped by Artery development-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	POLR3G →	+1.066	+0.506	.002	.008	3	4
LARGE_INTESTINE	PSMA4 →	+0.473	+0.803	.007	.004	3	4
LARGE_INTESTINE	NDUFAB1 →	+0.580	+0.834	.001	.002	3	4
LIVER	ARL14 →	-1.355	-0.974	.007	.001	2	4
KIDNEY	POMZP3 →	+0.843	+0.871	.004	.001	3	3
BLOOD_Leukemia	MARCHF3 →	-1.701	-0.830	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POLR3G by Artery development activity — LARGE_INTESTINE

Explore this box plot interactively →