Endothelial cell fate commitment

Across TCGA patient cohorts, RNA activity of the Endothelial cell fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NR2F2-AS1, GPRC5D, and FAM126A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endothelial cell fate commitment activity versus NR2F2-AS1 in BRCA (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NR2F2-AS1 →	+0.293	+0.439	<.001	<.001	3	4
GBM	GPRC5D →	-0.340	-0.416	.002	.006	3	3
GBM	FAM126A →	+0.464	+0.550	.008	.004	3	3
GBM	MIR3146 →	+0.591	+0.559	.002	.004	3	3
GBM	FKBP7 →	+0.255	+0.411	.009	.007	3	3
UCEC	TSPAN5 →	+1.120	+0.671	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060839 vs NR2F2-AS1 — BRCA

Explore this scatter interactively →