Endothelial cell fate commitment

Across TCGA cell cohorts, RNA activity of the Endothelial cell fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNN4, CREB3, and TAGLN2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCNN4 grouped by Endothelial cell fate commitment-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KCNN4 →	-2.359	-0.869	.002	.005	3	5
OVARY	CREB3 →	-0.724	-1.406	<.001	<.001	3	5
BONE	TAGLN2 →	-2.905	-1.652	.001	.002	3	5
BONE	ERLEC1 →	-1.022	-1.558	<.001	<.001	3	4
BONE	IL4R →	-2.187	-1.694	<.001	.002	3	4
KIDNEY	VDR →	-1.637	-1.267	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCNN4 by Endothelial cell fate commitment activity — SKIN

Explore this box plot interactively →